Metabolism of Drugs. XX. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3, 5-dimethylbarbituric Acid). (9). Interconversion of 3-Keto-MHB (5-(3-Oxo-1-cyclohexenyl)-3, 5-dimethylbarbituric Acid) and 3-OH-MHB (5-(3-Hydroxy-1-cyclohexenyl)-3, 5-dimethylbarbituric Acid) in the Rabbit.

抄録

In order to elucidate the transformation processes of MHB metabolites, 3-keto-MHB, α-3-OH-MHB, and β-3-OH-MHB were administered to rabbits. 3-Keto-nor-MHB, 3-keto-MHB, and 3-OH-MHB have been identified in every case from the 24-hour urine by buffered-paper chromatography. From these and the results of quantitative studies, it is concluded that the 3-ketone and 3-hydroxyl groups in the cyclohexenyl ring are interconvertible and the equilibrium is in favor of 3-OH-MHB.