Abstract
2-Dimethylaminoethyl phenyl ether, having alkyl chain of 8∼14 carbon atoms on the benzene ring in ortho- or para-position, were synthesized by condensation of alkylphenol with 2-dimethylaminoethyl chloride. The antiviral effects of these compounds were tested against the Nakayama strain of Japanese B encephalitis virus and the Lansing strain of poliomyelitis virus. 2-Dimethylaminoethyl o-octylphenyl ether and p-octylphenyl ether had antiviral activity against the Nakayama strain in vivo. 2-Dimethylaminoethyl o-octylphenyl ether, o-decylphenyl ether, and p-octylphenyl ether had antiviral activity against the Lansing strain in vitro.
