Abstract
Six kinds of 7-substituted s-triazolo [2, 3-a] pyrimidines, which are related to some isomeric compounds of natural purines and their antagonists, were prepared. Halogenation of 7-hydroxy- and 7-amino-s-triazolo [2, 3-a] pyrimidines with chlorine or bromine gave the corresponding 6-halogeno derivatives (VII), (VIII), (XI), and (XII). Some other 7-substituted 6-halogeno derivatives (XI), (XII), (XIII), and (XIV) were also derived from (IX) and (X) by the usual substitution reactions. Some of these compounds showed biological activity.
