Researches on Chemotherapeutic Drugs against Viruses. XXX. Synthesis and Antiviral Activity of 2-Dimethylaminoethyl Alkylbenzhydryl Ether.

Abstract

Compounds of 2-dimethylaminoethyl p-alkylbenzhydryl ether and p, p'-dialkylbenzbydryl ether series were synthesized and their activity was examined using the Nakayama strain of Japanese B encephalitis and the PR-8 strain of influenza A virus. p, p'-Dipropyl-, p, p'-dibutyl, and p, p'-dibutyl derivatives were found to have considerable activity on the PR-8 strain in membrane culture, and p-dodecyl derivative was recognized to be effective on the Japanese B encephalitis virus in mice.