Abstract
The structure of δ-hydroxy-γ-oxo-L-norvaline was proposed for the new antibiotic, HON. This compound was synthesized through two different routes. Optical resolution of the racemate was achieved by fractional crystallization of brucine salts of N-acetyl-δ-hydroxy-γ-oxo-DL-norvaline. Physicochemical and microbiological properties of the synthesized δ-hydroxy-γ-oxo-L-norvaline revealed that this compound was identical with naturally occurring L-HON.
