Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Syntheses of Thiazolo-[5, 4-d]pyrimidine Derivatives and Related Compounds.
石館 守三由岐 英剛
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1960 年 8 巻 2 号 p. 131-136

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Heating of the sodium salt of 4-amino-5-acylamino-6-mercaptopyrimidine results in the formation of a purine derivative but its heating with dilute hydrochloric or sulfuric acid was found to give thiazolo[5, 4-d]pyrimidine derivatives. 5-Amino-6-mercaptopyrimidine derivatives react with nitrile to form thiazolo[5, 4-d]pyrimidine derivatives, while they react with monochloroacetic acid to form pyrimido[4, 5-b][1, 4]thiazine derivatives, and with nitrous acid to form thiadiazolo[5, 4-d]pyrimidine derivatives.

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© The Pharmaceutical Society of Japan
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