Studies on Thiophene Derivatives. V. Syntheses of 3-Arylpropenamides.

Abstract

As some thiophene derivatives have interesting pharmacological actions, some new 3-arylpropenamides having thiophene ring were synthesized. The reactions of amines and 3-arylpropenoyl chloride, which were synthesized from 3, 3-di(2-thienyl)-3-hydroxypropionic acid, 3-phenyl-3-(2-thienyl)-3-hydroxypropionic acid, or 3-(2-thienyl)propenoic acid with thionyl chloride, gave the corresponding derivatives of propenamides.