Studies on the Constituents of Umbelliferae Plants. II. Isolation of the Active Principles of Ligusticum Root

Abstract

Isolation of active principles in the ligusticum root (Hokkai-Toki) was attempted. Anticholinergic principles were traced by the Magnus method with rat intestine. Ligustilide, which is a new and the most active constituent was isolated. It is an isomer of butylphthalide. It was marked bluish fluorescence and decomposes rapidly on exposure to air.