Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Reaction of Amide Homologs. V. Acetamidomethylation of Phenol and Anisole with N, N'-Methylenediacetamide.
関屋 実矢内原 昇増井 俊夫
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1961 年 9 巻 12 号 p. 945-948

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Acetamidomethylation of phenol and anisole was carried out by heating with N, N'-methylenediacetamide and phosphoryl chloride. Formation of N-(2-and 4-hydroxybenzyl) acetamides resulted in the case of phenol and formation of N-(4-methylbenzyl) acetamide in the case of anisole.
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© The Pharmaceutical Society of Japan
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