Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Carcinostatic Substances. XXXVIII. Chemical and Antitumor Properties of Monofunctional Derivatives of Nitrogen Mustard.
Kenichi Sawatari
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1961 Volume 9 Issue 12 Pages 996-999

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Abstract
Supported by the fact that N-methyl-N-2-chloroethyl-3-chloropropylamine exhibited a strong antitumor effect on Yoshida sarcoma or series of rat ascites hepatomas, eight derivatives of nitrogen mustard were newly synthesized, which have only one but highly reactive 2-chloroethyl group in a molecule. Antitumor test of these compounds on Yoshida sarcoma was, however, negative.
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© The Pharmaceutical Society of Japan
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