Studies on Thiamine Analogs ; Synthesis of 3-[(2, 4-Dioxo-1, 2, 3, 4-tetrahydro-5-pyrimidinyl) methyl]-4-methyl-5-(2-hydroxyethyl) thiazolium Nitrate.

Abstract

A new thiamine analog, 3- (2, 4-dioxo-1, 2, 3, 4-tetrahydro-5-pyrimidinyl) methyl-4-methyl-5- (2-hydroxyethyl) thiazolium nitrate (II) was synthesized from 5-cyanouracil (III). In the course of the reduction of (III), thymine was obtained besides the amine (IV). Further, a new method for obtaining (IV) was found.