Analytical Studies on Antileprous Drugs. V. On the Metabolic Difference of Promin and 4, 4'-Diaminodiphenyl Sulfone in the Urine and Plasma of Rabbits

Abstract

Metabolic difference between Promin and 4, 4'-diaminodiphenyl sulfone was investigated using urine and plasma of rabbits. It was clarified that Promin is metabolized mainly to N-glucoside of 4, 4'-diaminodiphenyl sulfone, receiving desulfonation. Further, N-conjugation was not clearly proved, being different from 4, 4'-diaminodiphenyl sulfone which was metabolized to mono-N-conjugates.