Studies on the Constituents of Digitalis purpurea L. XXV. A New Cardiotonic Glycoside, Acetylglucogitoroside and Digitalinum verum Monoacetate from Digitalis Seeds.

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The structure of substances A-II' and A-III', newly isolated from digitalis seeds, was examined. It was found that the mild acid hydrolysis of substance A-II' afforded gitoxigenin and acetyldigilanidobiose, and by strophanthobiase, this glycoside changid to mono-acetylgitoroside. Therefore, substance A-II' is formulated as gitoxigenin glucosido-acetyl-digitoxoside and it was named acetylglucogitoroside. Substance A-III'was examined by drastic acid hydrolysis and Mannich hydrolysis. Its acetylation gave digitalinum verum hexaacetate. Further, this glycoside was found to be identical with digitalinum verum monoacetate.