Studies on Decomposition and Stabilization of Drugs in Solution. VIII. Chemical Kinetic Studies on Aqueous Solution of Succinylcholine Chloride. (1). Separatory Determination of Succinylcholine Chloride in Hydrolyzed Products.

Abstract

Separation of partially hydrolyzed products of succinylcholine chloride in various buffered solutions by ion exchanger chromatography was attempted using a strong acid-type cation exchanger (R-Na form). It was concluded that succinylcholine chloride could be satisfactorily separated from the degradation products. Succinylcholine chloride and succinylmonocholine chloride were not hydrolyzed during elution. The recovery of these choline esters was within 2% of the theoretical values. It was ascertained that the decomposition of succinylcholine chloride in various buffered solutions could be investigated by this separatory method from the standpoint of chemical kinetics.