Translocation of HSP27 and MKBP in Ischemic Heart

Ken-ichi Yoshida; Toshihiko Aki; Kazuki Harada; Kazi M.A. Shama; Yasuhisa Kamoda; Atsushi Suzuki; Shigeo Ohno

doi:10.1247/csf.24.181

REGULAR ARTICLES

Translocation of HSP27 and MKBP in Ischemic Heart

Ken-ichi Yoshida, Toshihiko Aki, Kazuki Harada, Kazi M.A. Shama, Yasuhisa Kamoda, Atsushi Suzuki, Shigeo Ohno

著者情報

キーワード: HSP27, MKBP, translocation, ischemia, myofibril, oxidative stress

ジャーナルフリー

1999 年 24 巻 4 号 p. 181-185

DOI https://doi.org/10.1247/csf.24.181

詳細

抄録

HSP27 and MKBP translocate from the cytosolic to myofibril fraction in ischemic rat heart as demonstrated by immunoblotting. Immunohistochemistry analysis showed that ischemia enhances the Z line labeling of HSP27 and MKBP. Two dimensional gel electrophoresis showed that ischemia increases the hyperphosphorylated form of HSP27. These data suggest that HSP27 and MKBP may be involved in the Z line protection against postischemic reperfusion injury.

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