Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
ISSN-L : 0386-7196
Morphology and Function of Y-1 Cells. Round-up Phenomenon and Steroidogenesis
Akira KawaoiToshikazu UchidaTadao OkanoKaoru MatsumotoToshio Shikata
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1977 年 2 巻 4 号 p. 297-306

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The relationship was analyzed between cell morphology and steroidogenesis of Y-1 cells to dibutyryl cyclic AMP in dose-related, as well as time sequence responses. Rounded cells were confirmed to be active in steroidogenesis. The time course study showed a bi-phasic pattern of steroid output, i.e., the first phase of 8 h showed a low secretion rate followed by a later accelerated phase for at least 24 h. In stimulant-free medium, most round-up cells showed a return to a flat and polygonal shape within 5 h of incubation. However, the elevated steroidogenic activity persisted for at least 7 h.
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© Japan Society for Cell Biology
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