抄録
Changes in intracellular concentrations of adenosine 3', 5'-monophosphate (cAMP) and guanosine 3', 5'-monophosphate (cGMP) were investigated in primary cultures of chick embryonic muscle cells grown in the presence of 5'-bromodeoxyuridine (BUdR). Cell fusion was completely in-hibited in BUdR-treated cultures; however, the effect was reversed when the BUdR-containing medium was replaced with normal medium. As in control cultures, a significant increase in the ratio of cAMP-to-cGMP was observed during the first few days in both the BUdR-treated and the BUdR-released cultures. The data indicate that cell fusion is not a necessary step for concentra-tion changes in cyclic nucleotides, which means that these changes might be acause but not an effect of myoblast fusion.
