Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
ISSN-L : 0386-7196
Phosphoinositide Signalling Enzymes in Human T Lymphocytes : Modulation of Phosphoinositidase C Isoform Gamma 1 upon Interferon Treatment
Amelia CataldiRosa Alba RanaAntonio CaracinoAngela di BaldassarreIole RobuffoSebastiano Miscia
Author information

1995 Volume 20 Issue 2 Pages 143-149


In human T lymphocytes immunohlotting analysis of phosphoinositidase C (PIC) isoforms has shown that gamma 1 is the most represented isoform both at the cytoplasmic and nuclear level, and that interferon beta produces, within 90min of treatment, an increase of its expression. These results, also supported by immunoelectronmicroscopic investigation, strongly suggest the involvement of PIC gamma1 in the cascade of molecular events generated by the interaction between interferon and its cell surface receptors.

Information related to the author
© Japan Society for Cell Biology
Previous article Next article