Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
ISSN-L : 0386-7196
Phosphoinositide Signalling Enzymes in Human T Lymphocytes : Modulation of Phosphoinositidase C Isoform Gamma 1 upon Interferon Treatment
Amelia CataldiRosa Alba RanaAntonio CaracinoAngela di BaldassarreIole RobuffoSebastiano Miscia
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1995 Volume 20 Issue 2 Pages 143-149

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Abstract

In human T lymphocytes immunohlotting analysis of phosphoinositidase C (PIC) isoforms has shown that gamma 1 is the most represented isoform both at the cytoplasmic and nuclear level, and that interferon beta produces, within 90min of treatment, an increase of its expression. These results, also supported by immunoelectronmicroscopic investigation, strongly suggest the involvement of PIC gamma1 in the cascade of molecular events generated by the interaction between interferon and its cell surface receptors.

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© Japan Society for Cell Biology
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