Clinical Application for Intra-coronary NanoDDS Devices

Abstract

Drug eluting stent on the market at present is feared about serious side effects after use (Acute coronary syndrome caused by delayed thrombosis). It is suggested that delayed thrombosis comes from inflammatory reaction, fibrin deposition, and delayed re-endothelialization.　We have already succeeded in the development of stent platform that has the function of Nano DDS using electro-deposition coating technology.　In this review, we summarize the results of Pulse-Wave Infusion Catheter and statin nanoparticle eluting stent acquiring Proof of Concept by the porcine coronary-arteries models, with describing the outline of stent platform that has the function of Nano DDS.