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Volume 27 (2012)
- Issue 5 Pages 342-
- Issue 4 Pages 246-
- Issue 3 Pages 156-
- Issue 2 Pages 76-
- Issue 1 Pages 10-
Volume 27, Issue 4
SEPTEMBER
Displaying 1-6 of 6 articles from this issue
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Feature articles “technology to support the therapy of next generation” Editor :Yasuhiko Tabata
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Yasufumi Kaneda2012 Volume 27 Issue 4 Pages 246-256
Published: September 30, 2012
Released on J-STAGE: December 28, 2012
JOURNAL FREE ACCESSMuch attention has been paid to stem cell therapy. Current strategy is the use of pluripotent stem cells such as embryonal stem cells or induced pluripotent stem cells. Recently, it is found that stem cells derived from various tissues such as bone marrow and adipose tissue may have potential to regenerate inured tissues. However, as far as transplantation of stem cells or differentiated cells from stem cells is involved, physiological tissue regeneration may not be achieved. Furthermore, cell-transplantation therapy may not be widely spread in the world. Gene therapy for neovascularization using angiogenic genes has presented a new concept for tissue regeneration. A novel strategy for tissue regeneration is the recruitment of stem cells to injured tissues and the induction of physiological differentiation of stem cells for tissue repair. Several factors have been reported to achieve in vivo tissue regeneration. For example, HMGB1 (high mobility group protein 1), a multifunctional protein, can egress mesenchymal stem cells from bone marrow and SDF-1 (stromal cell derived factor-1) may be associated to recruit those stem cells to injured tissues. Herein, I introduce the current status of recruitment of stem cells for tissue repair.View full abstractDownload PDF (1373K) -
Yoko Obata, Tomoya Nishino, Shigeru Kohno2012 Volume 27 Issue 4 Pages 257-266
Published: September 30, 2012
Released on J-STAGE: December 28, 2012
JOURNAL FREE ACCESSChronic kidney disease (CKD) is known to be a risk factor for end stage renal disease (ESRD) and cardiovascular disease. Therefore, the development of new treatments for CKD is important and necessary. However, there is no established therapy for glomerulosclerosis and renal interstitial fibrosis, which are seen in the kidney of ESRD patients. Recent advances in basic research on the mechanism of fibrosis leads to discovery of fibrosis relating genes or factors. Some anti-fibrotic approaches for targeting these factors have been reported. In this review, we introduce several technologies and methodology using drug delivery system for fibrosis in nephrology.View full abstractDownload PDF (1720K) -
Hiroshi Nakase, Minoru Matsuura2012 Volume 27 Issue 4 Pages 267-274
Published: September 30, 2012
Released on J-STAGE: December 28, 2012
JOURNAL FREE ACCESSMany gastroenterologists have performed various treatments on several diseases such as inflammatory diseases and neoplastic diseases. Therefore, in the field of Gastroenterology, drug delivery system (DDS) is absolutely required for avoidance of drug-induced side effects. Development of DDS with polymeric materials such as biodegradable microspheres, etc., which could carry drugs and cytokines to targeted gastrointestinal tracts and liver, would contribute to future therapeutic strategy for gastrointestinal diseases.View full abstractDownload PDF (1778K) -
Kaku Nakano, Takeo Yufu, Kensuke Egashira2012 Volume 27 Issue 4 Pages 275-282
Published: September 30, 2012
Released on J-STAGE: December 28, 2012
JOURNAL FREE ACCESSDrug eluting stent on the market at present is feared about serious side effects after use (Acute coronary syndrome caused by delayed thrombosis). It is suggested that delayed thrombosis comes from inflammatory reaction, fibrin deposition, and delayed re-endothelialization. We have already succeeded in the development of stent platform that has the function of Nano DDS using electro-deposition coating technology. In this review, we summarize the results of Pulse-Wave Infusion Catheter and statin nanoparticle eluting stent acquiring Proof of Concept by the porcine coronary-arteries models, with describing the outline of stent platform that has the function of Nano DDS.View full abstractDownload PDF (1570K) -
Ryosuke Kuroda, Tomoaki Fukui, Kazunari Ishida, Ken Sasaki, Yasuhiko T ...2012 Volume 27 Issue 4 Pages 283-288
Published: September 30, 2012
Released on J-STAGE: December 28, 2012
JOURNAL FREE ACCESSGenerally, bone has good self-repair ability, however, critical large amounts of bone defects after fracture or resection of malignant bone tumor, which are challenging for orthopaedic surgeons. Also the healing potential of the injured ligament, cartilage, spinal disc are extremely poor. Tissue engineering and regenerative medicine have attracted much attention as new therapeutic technologies that induce tissue regeneration by making use of scaffolds, growth factors, cells, or their combination in orthopaedic field. Drug delivery system is one of the most important methods for regenerative medicine. Gelatin hydrogel, which control the release of containing growth factors, is very attractive biomaterials for tissue regeneration via enhanced angiogenesis and recruitment of stem cells.View full abstractDownload PDF (480K) -
Yoshikatsu Saiki, Yumi Sugawara2012 Volume 27 Issue 4 Pages 289-295
Published: September 30, 2012
Released on J-STAGE: December 28, 2012
JOURNAL FREE ACCESSThere have been variable evolving technologies for drug delivery system (DDS) applied in cardiovascular surgery. Enormous clinical success with drug eluting stent enhanced cardiac surgical researchers to expand the concept of local delivery of effective agents. Representative agents introduced for those technologies include basic fibroblast growth factor(bFGF) and antibiotics, especially vancomycin. With these agents, numerous attempts have been made to treat peripheral tissue ischemia, intractable graft infection, catheter-related infection and to enhance sternal healing process via angiogenesis. Interim results from in vitro and in vivo experiments are promising. Above all, bFGF slow-release system has already launched in clinical arena, and has yielded some therapeutic effect in the treatment of critical limb ischemia. In terms of the DDS application for infection control, antibiotic-loaded polymethylmethacrylate beads for the treatment of extracavitary prosthetic vascular graft infections have been utilized in Western countries. In this country, gelatin-coated biodegradable polyglycolic acid with bFGF has been tested for the patients undergoing aortic aneurysmal repair to prevent pseudoaneurysmal formation in long term occurring at the aortic anastomotic site.View full abstractDownload PDF (1487K)
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