Phase separated membranes for transdermal drug delivery system

抄録

Phase separated composite membranes composed of pressure sensitive adhesive polymers and non adhesive polymers were prepared by interpenetrating each polymer component as an alternative approach in the design of a transdermal delivery device. Acrylic polymers were used for an adhesive polymer domain and crosslinked polyethers, such as poly (ethylene oxide)-poly(propylene oxide) block copolymer or crosslinked poly(propylene oxide), were utilized as a non adhesive polymers. The T_g study of the composite membranes revealed a phase separated structure with partial mixing. The membrane adhesiveness was linearly proportional to the amount of adhesive component in the membranes. The tested drugs of β-estradiol, testosterone, hydrocortisone, and nicotine showed preferential permeation through one domain in the membranes. This permeation specificity could be related to the experimental conditions (solvent compositions in diffusion cell compartments) and the interactions between polymer components and drugs for the particular systems used in this study. These results indicate that controlled permeability and adhesive strength can be obtained by a composite membrane.