抄録
Patients with metastatic hepatocelluiar carcinoma (HCC) and impossibility to cut out primary HCC were treated carcinostatic transcatheter arterial embolization (TAE) combinated intra-arterial injected chemo-lipiodolization therapy. In this study, we were investigated constituents THP-emulsion using non-ionic contrast media (NCM), iopamidol (IOP) and iohexol (OMN), in pirarubicin (THP) emulsion, to use TAE combinated chemo-lipiodolization therapy for HCC. In these emulsion, water phase was NCM used as solvents for THP, oily phase was lipiodol ultrafluid (LPN). THP-emulsion was prepared by high pressure homogenization using two syringes jointed three-way cock. Stable w/o and o/w types of THP-emulsion were uniform at particle size, independent on kind of NCM. The OMN used to THP-emulsion was easier to decompose into doxorubicin. Therefore, water phase of THP-emulsion was suitable to more TOP than OMN. Stability of THP in NCM was examined and IOP was selected as the solvent. Further, there was non disfunction, transaminase of GOT and GPT in normal liver when rats were received intra arterial injection of each THP-emulsion. We could propose THP-emulsion using IOP and LPD as constituents to carry pre clinical study for TAE combinated chemo-lipiodolization therapy for HCC.
