微粒子製剤設計とDDS

リポソームの遺伝子治療への応用

抄録

Liposomes are synthetic lipid vesicles able to entrap drugs or genes within their aqueous compartment and/or lipid bilayer, and they also have been regarded as a useful delivery system, their potential for in vivo gene transfer has been reported. Because liposomes are low levels of toxicity and immunogenicity and they are easy to prepare in large quantity. In addition, cell or tissue specificity can be conferred on liposomes by conjugation or association with specific proteins or antibodies (immunoliposomes). Therefore liposomes are one of the most promising vectors in human gene therapy, especially cationic liposomes. Cationic liposomes hind DNA to form complexes with high affinity to cell membrane or entrap DNA into their compartment, resulting in delivering DNA into cells efficiently. Based on these results, clinical trials of human gene therapy using cationic liposomes have been conducted, Here, we introduce human gene therapies using the liposomes including our cases.