三元共重合体PLA-PEG-PLAを用いたナノパーティクル

抄録

This review is summarized about nanoparticles consisted of triblock-copolymer, poly(L-lactic acid) (PLA)-poly(oxyethylene) (PEG)-PLA. This nanoparticles are characterized using scanning electron microscope (SEM), small-angle X-ray scattering (SAXA) technique and electron spectroscopy for chemical analysis (ESCA). The release of progesterone-loaded PLA-PEG-PLA nanoparticles can be controlled by contents of hydrophilic segments. The release enhancement depended on the PEG content and PEG Mw. Many researchers have been studying the surface modification of nanoparticles using amphoteric compound such as surfactants, albumin, and the use of copolymers, which have both the hydrophilic and hydrophobic domain for the reticuloendothelial system (RES) avoiding system. We showed the possibility of the RES avoiding nanoparticles using PLA-PEG-PLA triblock copolymer as like PLA-PEG diblock copolymer nanoparticles. The contents of PEG and the PEG Mw affected on the RES avoiding ability of nanoparticles. We studied the multiple dose of the PLA-PEG-PLA nanoparticles, and the nanoparticles could control the plasma concentration of drug. The more detail studies, specially the pharmacokinetics and safety will be necessary for clinical use of nanoparticles.