Comparison of the image intensity after injection of contrast media using dynamic computed tomography (CT) technique was carried out between angiotensin II human (TY-10721) induced hypertension (HT) and normotensive (NT) state in the patients with various metastatic liver tumor. Serial scanning time after 50 ml/10 sec of bolus injection of the contrast media (Iopamidol) was 0, 10, 30, 45, 60, 90 sec, 2, 3, 5, 8, 10, 15 min and each scan time was 4.5 sec. The relative ratio of each CT number in the ROI (region of interest) were calculated as the values before the injection of contrast media was estimated at 100%. The ratio of the peak CT numbers (HT/NT) was 115.9±15.7 (mean±SD) in tumor areas, and 89.8±21.6 in the normal liver, 94.6±10.2 in the muscle, 104.1±12.4 in the bone and 133.8±42.6 in the abdominal aorta. Moreover, in a comparison of AUC ratio between HT and NT during 0 to 10 minutes after the injection, in tumor areas it was 164.2±78.9, but in other normal tissues those were 60.4±45.7 (liver), 41.9±32.3 (muscle), 57.0±44.1 (bene) and 86.8±20.8 (aorta), respectively. The ratios of the peak and AUC between HT/ NT were significantly increased in only tumor areas (t-test ; P<0.001), though in all the other normal tissues, those were reduced. In a series of experiments and clinical results, selective increase of blood flow in the tumor tissues and significant increase of clinical effects were observed under TY-10721 induced HT. In addition to these evidences, this trial could show that selective enhancement of the medium delivery to tumor tissues was also obtained in the cancer patients.
