ペプロマイシン封入W/O/W型リピオドールエマルションによる食道癌リンパ節転移に対する targeting 療法

―基礎実験―

抄録

The purpose of this experimental study is to analyze the efficacy of W/O/W type lipiodol emulsion containing peplomycin for the targeting therapy of regional lymph node metastasis of the esophageal cancer. The emulsion was newly perpared with two separated steps of emulsification, and it was appropriate for enhancement of an affinity to lymphatics. The emulsion containing peplomycin (10-20 mg) was endoscopically injected into the submucosal layer of the intrathoracic middle esophagus of the canines. Seven days after the injection, canines were sacrified, and the esophagus and intrathoracic lymph nodes along with other organs were resected. The retention of the emulsion was detected by X-ray examination, and the emulsion was only observed in the esophagus and some of regional lymph nodes. PEP concentration in the esophagus with detection of the emulsion (32.12±11.38 μg/g wet tissue in average)was much higher than the other organs. PEP concentration of regional lymph nodes with retention (7.76±3.32 μg/g in average) was higher than that in lymph nodes without detection of the emulsion (0.64±0.64 μg/g in average). Therefore the emulsion was appropriate for bringing about slow drug release. These results indicated that this emulsion might be useful for the targeting therapy for lymph node metastasis of the esophageal cancer.