Isotryptoquivaline F, a new quinazolinone derivative with anti TNF-α activity from Aspergillus sp. CM9a

Heng Xue; Qingyan Xu; Chunhua Lu; Yuemao Shen

doi:10.5582/ddt.2014.01039

Brief Reports

Isotryptoquivaline F, a new quinazolinone derivative with anti TNF-α activity from Aspergillus sp. CM9a

Heng Xue, Qingyan Xu, Chunhua Lu, Yuemao Shen

Author information

Keywords: Cephalotaxus mannii, TNF-α antagonistic effect, anti-inflammatory drugs

JOURNAL FREE ACCESS

2014 Volume 8 Issue 5 Pages 208-211

DOI https://doi.org/10.5582/ddt.2014.01039

Details

Abstract

Isotryptoquivaline F (1) was isolated from Aspergillus sp. CM9a, an endophytic fungus of Cephalotaxus mannii. The structure was elucidated by extensively 1D and 2D NMR and HR ESI MS spectroscopy. It has good TNF-α antagonistic effect, and can be used for anti-inflammatory drugs or other bioactive leading drugs.

Corresponding author

Register with J-STAGE for free!