Keynote Speech

抄録

In this study， using flow cytometric analysis， the effects of purified IgG antimelanocyte antibodies (IgG-anti MC)， from patients with active vitiligo on T cell antigen expression were studied. The spontaneous expression of CD4， CD8， CD25 and TCR on patients' T cells was not dignificantly different from those of normal controls. However， after incubation with IgG-anti-MC， a significant decrease of these markers was noticed in healthy controls， but not in patients. These results suggest 2 possiblities: 1)dysfunction of T cell or 2)that the expression of T cell antigens in normal individuals can be inhibited by antimelanocyte antibodies， but vitiligo patients are resistant to the autoantibodies.