Effects of Dose of Recombinant Human BMP-2 on Bone Formation at Palatal Sites in Young and Old Rats

Kozo YAMAJI; Masamitsu KAWANAMI; Atsushi MATSUMOTO; Tomoomi ODAJIMA; Yoshihiro NISHITANI; Kensuke IWASAKA; Keiko YOSHIMITSU; Masahiro YOSHIYAMA

doi:10.4012/dmj.26.481

Original papers

Effects of Dose of Recombinant Human BMP-2 on Bone Formation at Palatal Sites in Young and Old Rats

Kozo YAMAJI, Masamitsu KAWANAMI, Atsushi MATSUMOTO, Tomoomi ODAJIMA, Yoshihiro NISHITANI, Kensuke IWASAKA, Keiko YOSHIMITSU, Masahiro YOSHIYAMA

Author information

Kozo YAMAJI
Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Masamitsu KAWANAMI
Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine
Atsushi MATSUMOTO
Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine
Tomoomi ODAJIMA
Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine
Yoshihiro NISHITANI
Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kensuke IWASAKA
Department of Restorative and Biomaterials Sciences, Division of Operative Dentistry, Meikai University School of Dentistry
Keiko YOSHIMITSU
Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Masahiro YOSHIYAMA
Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Keywords: Dose of rhBMP-2, Bone formation, Aging

JOURNAL FREE ACCESS

2007 Volume 26 Issue 4 Pages 481-486

DOI https://doi.org/10.4012/dmj.26.481

Details

Abstract

This study was designed to examine the effects of dose of recombinant human BMP-2 (rhBMP-2) on bone formation at palatal sites in 10-week-old (10w) and 70-week-old (70w) rats, when combined with a polylactate-polyglycolate copolymer/gelatine sponge (PGS).
New bone formation was observed at six weeks after implantation. In the 10w rats, thickness of new bone (TNB) increased as the dosage increased from 0 μg to 4 μg, and decreased significantly as the dosage increased from 8 μg to 24 μg. In contrast, in the 70w rats, TNB increased as the dosage increased from 0 μg to 16 μg, and did not significantly change as the dosage increased from 16 μg to 24 μg.
These results suggest that the most effective dosage of rhBMP-2 for induction of bone formation varies according to age.

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