Synthesis, biocompatibility and mechanical properties of ZrO₂-Al₂O₃ ceramics composites

抄録

This study evaluated cell viability, microhardness and flexural strength of two ceramic composites systems (Z_A and A_Z), pure alumina and zirconia. There were prepared homogeneous mixtures of 78wt%Al₂O₃+20wt%3Y-TZP+2wt%Al₂O₃w (A_Z) and 80wt%3YTZP+18wt%Al₂O₃+2wt%Al₂O₃w (ZA), as well as 3Y-TZP (Z), pure Al₂O₃ (A) and commercial monolithic 3Y-TZP (Zc). Also mouse fibroblast cells 3T3-L1 and a MTT test was carried out at 24, 48 and 72 h. The surfaces were observed with SEM and the microhardness and three-point flexural strength values were estimated. The absolute microhardness values were: A>A_Z>Z>Zc>Z_A. Flexural strength of Zc, Z, and Z_A were around double than A_Z and A. All groups showed high biocompatibility trough cell viability values at 24, 48 and 72 h. Factors like grain shape, grain size and homogeneous or heterogeneous grain distributions may play an important role in physical, mechanical and biological properties of the ceramic composites.