Dental Materials Journal
Online ISSN : 1881-1361
Print ISSN : 0287-4547
ISSN-L : 0287-4547

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Enhanced infiltration of myoblasts into collagen scaffolds loaded with engineered basic fibroblast growth factor
Tamamo MATSUYAMAShiina PASANENFumino FUTAMIAyari KATOIsao HIRATASouichi YANAMOTOKoichi KATO
著者情報
ジャーナル オープンアクセス 早期公開

論文ID: 2024-314

この記事には本公開記事があります。
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Tongue reconstruction after cancer resection often involves the use of free skin flaps. However, this strategy has limitations. To overcome these issues, tissue engineering approaches using basic fibroblast growth factor (bFGF) have been investigated to promote tongue muscle regeneration. In this study, a chimeric protein consisting of bFGF and a collagen-binding peptide (CBP-bFGF) was evaluated for its ability to promote myoblast infiltration into collagen-based scaffolds. Results showed that CBP-bFGF promoted the migration of C2C12 myoblasts and their infiltration into collagen sponges. Based on these observations, we propose that the binding of CBP-bFGF with a collagen sponge provides one of the options for accelerating tongue muscle regeneration.

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© The Japanese Society for Dental Materials and Devices

This is an open access article under the CC BY license
https://creativecommons.org/licenses/by/4.0/
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