Dental Materials Journal
Online ISSN : 1881-1361
Print ISSN : 0287-4547
ISSN-L : 0287-4547
Changes in 1H-NMR Chemical Shifts of Bis-GMA and Its Related Methacrylates Induced by Their Interaction with Phosphatidylcholine/Cholesterol Liposomes
Seiichiro FUJISAWAYoshinori KADOMAYasuo KOMODA
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1991 Volume 10 Issue 2 Pages 121-127,231


To clarify the hemolytic mechanism of Bis-GMA and its related methacrylates, the interaction of five methacrylates (Bis-GMA, MMA, NPGDMA, TEGDMA, and UDMA) with DPPC/Cholesterol (CS) liposomes, as a model for erythrocyte membranes, was studied by 1H-NMR spectroscopy. Exogenous Bis-GMA partitioning into the DPPC/CS liposomes caused disappearances of its proton signals. With NPGDMA, its signals broadened markedly in DPPC/CS liposomes. UDMA partitioning caused changes in chemical shifts to a higher field, whereas MMA and TEGDMA partitioning did not cause any changes in chemical shifts. It was concluded from these observations that Bis-GMA has a stronger interaction with the DPPC/CS liposomes than the other methacrylates used. The high hemolytic activity of Bis-GMA reported previously3, 12) seemed to be due to its migration into the lipid bilayer of phospholipids containing CS in erythrocyte membranes.

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© The Japanese Society for Dental Materials and Devices
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