Three Novel Single Nucleotide Polymorphisms (SNPs) of the CYP2B6 Gene in Japanese Individuals

抄録

  We sequenced all exons and exon-intron junctions of the CYP2B6 gene from 200 Japanese individuals. We found three novel single nucleotide polymorphisms (SNPs) (1375A>G, 1427G>A and 1454A>T) causing amino acid substitutions (Met⁴⁵⁹Val, Gly⁴⁷⁶Asp and Gln⁴⁸⁵Leu in exon 9), respectively.
  The detected SNP was as follows:
  1) SNP, 031226Hiratsuka01; GENE NAME, CYP2B6; ACCESSION NUMBER, AC023172; LENGTH, 25 base; 5′-CAGAACTTCTCCA/GTGGCCAGCCCCG-3′.
  2) SNP, 031226Hiratsuka02; GENE NAME, CYP2B6; ACCESSION NUMBER, AC023172; LENGTH, 25 base; 5′-CCCAGGAGTGTGG/ATGTGGGCAAAAT-3′.
  3) SNP, 031226Hiratsuka03; GENE NAME, CYP2B6; ACCESSION NUMBER, AC023172; LENGTH, 25 base; 5′-CCCCAACATACCA/TGATCCGCTTCCT-3′.