3b06 A549ヒト肺癌細胞株に対するクラウンエーテル含有液晶性化合物の抗腫瘍効果(ソフトマター,口頭発表,2012年日本液晶学会討論会)

抄録

We prepared some crown ether derivatives possessing phenylpyrimidine or cyanobiphenyl as a mesogenic unit. Those compounds were tested against A549 human lung cancer cell line. They were found to show marked suppression of cell proliferation. The cell cycle analysis indicates that the crown ether derivatives induce cell death in the tumor cell. Furthermore, we investigated effects of mesogenic structure on the anticancer activity. The phenylpyrimidine derivatives induced necroptosis, while the cyanobiphenyl derivatives induced necrosis.