Biosensor for the Detection of Endocrine Disrupting Chemicals Based on the Degradation of Cell Membrane Model Immobilized on QCM and its Application to the Detection of Nonylphenol

抄録

For detection of endocrine disrupting chemicals (EDCs), a novel biosensor based on the degradation of cell membrane model by EDCs is proposed. As a cell membrane model, liposome cluster was prepared from cationic liposome and membrane protein bacteriorhodopsin. We fabricated a biosensor to detect EDCs by immobilization of the cluster on quartz crystal microbalance (QCM) through ionic alkyl thiol. Nonylphenol was examined as representative EDCs and the sensor detected nonylphenol at the range of 1.0 ppb-1.0 ppm.