GlycyrrhizinのCorticoid作用の本態に関する実験的研究

抄録

A study is made of effects of glycyrrhizin on the metabolism of hydrocortisone using rat liver homogenate or its supernatant.
The result obtained are as follows :
1. Glycyrrhizin inhibited the degradation of sidechain as well as the reduction of Δ₄-3 ketone.
2. Glycyrrhezinic acid was found to be the very agent to inhibit the metabolism of hydrocortisone.
3. Glycyrrhizin had no effect upon the degradation of sidechain of tetrahydrohydrocortisone. It is assumed that glycyrrhizin specifically inhibited the reduction of Δ₄-3 ketone and acted indirectly upon the degradation of sidechain.
4. Glycyrrhizin also inhibited the reduction of Δ₄-3 ketone of DOC and progesterone.
5. It is suggested that glycyrrhizin inhibit competitively the metabolism of corticoid and manifest a corticoid-like action.