血清無機ヨードの測定法に関する検討とその臨床的意義

抄録

Though Plasma Inorganic Iodine (PII) levels have been reported by many authors, they differ from each other.
One theoretically reliable method for the estimation of PIT was devised, and experimentally testified for its reliability and compared with Stanley's method which has been believed most reliable. As a result, the author comfirmed that this method is an excellent one. In normal subjects and patients with various thyroid diseases PII was estimated with this method and their iodine metabolism was simultaneously studied.
On the other hand, correlation between PII and other clinical laboratory tests of thyroid function and effects of various drugs on PII were also investigated.
The results were as follows :
This method which estimates PII within 30 minutes only, is not only simple but more accurate. Correlation between this method and Stanley's was statistically significant (P<0.005).
With this method, the mean PII level and the standard deviation for 22 normal subjects were 0.44±0.24 μg/100 ml, and for 21 hyperthyroid patients were 0.21±0.18 μg/100 ml, that is, the latter was apparently lower than the former (P<0.01).
The mean PII level in 11 hypothyroid patients (0.78±0.49 μg/100 ml) was plainly higher and that in 17 patients of simple goiter showed a low level (0.26±0.23μg/100 ml).
PII levels in hyperthyroid patients who had received antithyroid drugs rose significantly to normal range in correlation with the improvement of their conditions.
Following the administration of thyroid hormone preparations, PIT levels in patients with simple goiter had a tendency to become higher but no change was observed in the PIT levels of hypothyroid patients. From these results it was suggested that PIT levels closely depended on the state of the thyroid function.
The PII levels rose following the sdministration of the iodide supplements (300 μg/ day) of a short duration (about a week), but increase was not found in a long-term administration (3 months). The closest negative correlation between PII and PM was found (correlation coefficinet-0.81, P<0.005).
PII levels in the euthyroid patients who had received both adrenocorticosteriod and anabolic steroid preparations were below normal.
Correlation between the PII and the renal clearance of iodide was not found.