Association of the serum irisin level with obstructive sleep apnea: a body mass index- and physical activity-matched study

Weijun Huang; Yupu Liu; Huajun Xu; Huaming Zhu; Jian Guan; Hongliang Yi; Jianyin Zou

doi:10.1507/endocrj.EJ19-0590

ORIGINAL

Association of the serum irisin level with obstructive sleep apnea: a body mass index- and physical activity-matched study

Weijun Huang, Yupu Liu, Huajun Xu, Huaming Zhu, Jian Guan, Hongliang Yi, Jianyin Zou

Author information

Weijun Huang
Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China
Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, 200233, China
Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China
Yupu Liu
Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China
Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, 200233, China
Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China
Huajun Xu
Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China
Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, 200233, China
Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China
Huaming Zhu
Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China
Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, 200233, China
Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China
Jian Guan
Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China
Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, 200233, China
Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China
Hongliang Yi
Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China
Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, 200233, China
Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China
Jianyin Zou
Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China
Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, 200233, China
Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China

Keywords: Obstructive sleep apnea, Irisin, Obesity, Physical activity

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2020 Volume 67 Issue 6 Pages 607-612

DOI https://doi.org/10.1507/endocrj.EJ19-0590

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Abstract

Obesity is strongly correlated with the pathogenesis of obstructive sleep apnea (OSA); myokines may play important roles in this condition. We performed a body mass index- (BMI) and physical activity- (PA) matched study to explore the relationship between the irisin level and OSA. Ninety-six consecutive participants were recruited. After matching in terms of BMI and PA, 28 OSA patients and 28 healthy controls were finally included. Whole-night laboratory-based polysomnography was used to identify OSA. The Recent Physical Activity Questionnaire and Epworth Sleepiness Scale Questionnaire were employed to assess PA over the past 4 weeks, and daytime sleepiness. We measured serum irisin, fasting blood glucose, and insulin levels in blood samples. The serum irisin concentrations differed significantly between the control, mild OSA, moderate OSA, and severe OSA groups (p < 0.001) and correlated significantly with the apnea/hypopnea index (AHI) (r = –0.787, p < 0.001). All of age, BMI, neck, waist and hip circumferences, fasting blood glucose level, and the Epworth Sleepiness Scale and PA scores were associated with irisin levels (p < 0.05). After adjustment for these factors, the serum irisin level was independently correlated with the AHI (r = –0.428, p = 0.002). On forward logistic regression analysis, the association remained significant in the final multiple regression model (β = –0.107, p < 0.001). The serum irisin concentration was significantly correlated with OSA severity, independently of BMI and PA. Further studies are needed to determine the molecular mechanisms in play.

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