Abstract
Metabolic syndrome (MetS) is occurrence of diabetes mellitus/glucose intolerance, arterial hypertension, central obesity, dyslipidemia and microalbuminuria in the same patient (definition by WHO). Presence of metabolic syndrome is associated with larger myocardial infarction size and complications following acute myocardial infarction. Two hundred and thirty patients with acute coronary syndromes were analyzed. Those with MetS (n=141) included patients with diabetes mellitus/glucose intolerance and at least two of the following criteria: hypertension, hypertriglyceridemia/low HDL cholesterol, android obesity/body mass index (BMI) ≥ 30, microalbuminuria. Control group did not meet criteria for MetS. Presence of heart failure was assigned according to Killip graduation. The MetS group had larger myocardial infarction size determined by peak creatin-kinase (CK) (1484±1354 vs. 981±890, p = 0.003) and creatin-kinase MB (141±117 vs. 95±78, p = 0.002). While in non-MetS group males had larger myocardial infarction than females, in MetS group females had larger myocardial infarction than males. Cardiac failure occurred more in MetS group of patients, again more emphasized in females. Occurrence of metabolic syndrome in acute coronary syndromes patients predisposes to larger myocardial infarction size, more on the account of female patients having MetS. MetS, again particularly in females predisposes to higher chance of having heart failure during acute coronary syndromes. Recognizing the female group with MetS as of higher risk for large myocardial infarction and heart failure leads us to take special attention on this patients.
