Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
Correlation among body composition and metabolic regulation in a male mouse model of Cushing’s syndrome
Masaaki UeharaHiroki YamazakiNoritada YoshikawaAkiko Kuribara-SoutaHirotoshi Tanaka
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JOURNALS FREE ACCESS Advance online publication

Article ID: EJ19-0205

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Abstract

Glucocorticoids play a critical role in the regulation of homeostasis, including metabolism. In patients with Cushing’s syndrome, chronic glucocorticoid excess disrupts physiological internal milieu, resulting in central obesity, muscle atrophy, fatty liver, and insulin resistance. However, the relationship among various metabolic effects of glucocorticoids remains unknown. In the present study, we studied a male mouse model of Cushing’s syndrome and indicated that glucocorticoid excess alters metabolic phenotype and body composition involving possible communication among skeletal muscle, liver, and adipose tissue.

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