Article ID: K07-102
Controversy still exists about whether vitamin D status is related to the severity of primary hyperparathyroidism (pHPT), although vitamin D insufficiency is frequent in pHPT. The present study was therefore performed to examine the relationships between vitamin D status and various parameters in 30 postmenopausal pHPT patients. BMD values were measured by dual-energy x-ray absorptiometry at the lumbar spine (L2-4), femoral neck (FN) and distal one third of the radius (Rad 1/3). Serum levels of 25 hydroxy-vitamn D3 [25 (OH) D] and 1,25-dihydroxy vitamin D3 [1,25(OH) 2D3] were 15.8 ± 3.5 μg/l and 69.3 ± 33.3 ng/l in pHPT patients, respectively. Serum levels of calcium and PTH seemed to be negatively correlated to serum 25 (OH) D levels, although the differences were not significant. However, when subjects with the highest serum PTH levels (PTH >1000 pg/ml) were excluded from the analysis, the correlation was significant between serum 25 (OH) D levels and PTH, indicating that vitamin D status affects the severity of pHPT when severe cases were excluded. In addition, serum levels of 1,25(OH)2D3 were significantly and negatively correlated to serum 25 (OH) D levels. On the other hand, serum levels of 25 (OH) D were significantly and positively correlated to BMD (Z-score) at the lumbar spine, but not at the radius and femoral neck; however, serum 25 (OH) D levels were not correlated to the levels of any bone metabolic indices measured. Moreover, serum levels of 25 (OH) D were not related to urinary calcium and the tubular reabsorption rate of phosphorus, and they were similar in groups with and without renal stones. In conclusion, vitamin D status seemed to be related to the severity of disease in postmenopausal patients with pHPT. In particular, the relationship between serum 25 (OH) D level and BMD at the lumbar spine was predominant.
