STUDIES ON ZINC METABOLISM II. EFFECT OF THE DIABETIC STATE ON ZINC METABOLISM: AN EXPERIMENTAL ASPECT
1963 年 10 巻 1 号 p. 1-8
詳細
1963 年 10 巻 1 号 p. 1-8
Zinc metabolism in diabetes was studied in depancreatized dogs and alloxan diabetic rabbits.
Urinary zinc excretion was markedly increased 4 or 5 days after the onset of diabetes and it maintained a relatively constant value of a five-to eight-fold increase so long as the diabetic state lasted. The magnitude of an increase of urine zinc in the experimetal animals was approximately equal to that observed in severe diabetic patients. Improvement of diabetic conditions tended to regain a normal pattern of zinc excretion.
There was also obtained the finding of an early and transient increase in zinc excretion which occurred immediately after administration of alloxan. Evidence has been obtained that such early and transient increase is not related to alloxan per se but to metabolites of alloxan such as purpureate and alloxanic acids. The diabetogenic action of alloxan has been discussed in the light of the present experimental findings.
