STUDIES ON ZINC METABOLISM III. EFFECT OF THE DIABETIC STATE ON ZINC METABOLISM: A CLINICAL ASPECT
1963 年 10 巻 1 号 p. 9-15
詳細
1963 年 10 巻 1 号 p. 9-15
Urinary zinc excretion was confirmed to be markedly increased in patients with diabetes mellitus. The magnitude of an increase of zinc in urine was well correlated with the severity of diabetes. Day-to-day variations of the 24 hour excretion of zinc in diabetic patients were found to be considerably slight. An effective treatment with insulin or antidiabetic sulfonylurea tended to restore a normal pattern of zinc excretion. These data could be interpreted in the light of the finding that the augmentation of chelating agents always results in an increase in urinary zinc excretion. The augmentation of endogenous chelating agents has been briefly discussed with reference to its influence upon the islets of the pancreas.
