抄録
Sixty male rats of Wistar-Imamichi strain castrated at the 45 days of age were decapitated at the 10, 30, 50, 55, 60, 180, 240, 300th and 421st postoperative day respectively. The anterior lobe of pituitary, adrenal and thyroid were investigated histologically. Commonly, in the control intact rats of various ages, the thyrotroph (T) was polygonal and the gonadotroph (G) spherical, together stainedwith PAS; with PAS-methylblue stain, T was PAS-purple, while G PAS-red; with aldehyde fuchsin stain, T positive but G negative. The significant proliferation of hypertrophied basophile cell was the main event following the prolonged castration. They belong exclusively to the castration cell. After the 150th postoperative day, most of them were transformed into so-called signet-ring cells containing the huge colloid mass; when they fell into an exhaustion, they gained the PAS-purple tincture, which may be concerned with the high density of the ground substance of the cell-body. In a moment T disappeared in the pituitary, the thyroid would be naturally expected to be atrophic. Nevertheless, the fact being contradictory to this expectation, thyroid provided no atrophic pattern, but rather the vigorous chronical response at the same level as by TSH administration. A expedited picture was no longer seen in adrenal cortex. From these observations, a question could naturally arise on the fixed classification of G and T. The monism is here tenable concerning the TSH and GTH secretion from a kind of basophile cell in the anterior lobe of pituitary.
