THE EFFECT OF GLUCOCORTICOID ON GLUCONEOGENESIS IN RATS WITH LIVER DAMAGE

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C¹⁴-incorporation into blood glucose and liver glycogen from C¹⁴-labelled alanine was studied in rats with acute or chronic CCl₄ liver damage.
In rats with CCl₄ liver damage, C¹⁴-incorporation from alanine into blood glucose and liver glycogen was found to be decreased, especially in rats with acute CCl₄ liver damage. Such a disturbed C¹⁴-incorporation was improved by the administration of 2.5mg of cortisone to rats with chronic CCl₄ poisoning. However, in rats with acute CCl₄ liver damage, cortisone treatment caused a marked increase in C¹⁴-incorporation into blood glucose and failed to increase C¹⁴-incorporation into liver glycogen.
The latter finding may be related to the increased incidence of steroid diabetes in patients with liver damage.