AN INHIBITORY EFFECT OF GLYCYRRHIZIN ON METABOLIC ACTIONS OF CORTISONE

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It has been previously shown in our laboratory that glycyrrhizin inhibits the antigranulomatous action of cortisone without affecting the anti-inflammatory action in rats. In the present paper, the work was extended to include the effect of glycyrrhizin on metabolic actions of cortisone in the liver of adrenalectomized rats. Daily injections of cortisone induced a several fold increase of liver glycogen content, tryptophan pyrrolase activity and incorporation of [1-¹⁴C] acetate into cholesterol in rat liver, while concomitant injections of glycyrrhizin blocked these metabolic actions of cortisone. Administration of glycyrrhizin by itself, however, had no effect on the action of cortisone.