抄録
The subcutaneous administration of Na-tartrate caused a picture of definite degeneration or necrosis in proximal convolution epithelial cells of the rabbit kidney.This, together with the data in the preceding communication (Yoshimura and Negishi, 1954) that the chemical did not influence upon the vasopressoreffect of kidney extract, casts a doubt on the Friedman and Kaplans'proximal convolution theory regarding the site of renin formation.
The subcutaneous administration of the chemical produced the evident sign of hypergranulation and endocrine activity in juxtaglomerular cells of the rabbit which contain no granules in normal state. This is considered to sufficiently weakened the ground of Goormaghtigh's juxtaglomerular cell theory coticerning the site of renin formation.
The subcutaneous administration of the chemical did not affect significantly the dark cells in the junctional and the collecting tubules, but some changes were recognized in them in both the inner striated portion of outer zone and inner zone of medulla.
