抄録
Simultaneous measurements of plasma renin activity (PRA), aldosterone concentration and serum potassium were carried out in 27 hyperthyroid, 10 hypothyroid patients and 22 normal controls. In 16 hyperthyroid patients these analyses were done after 90mg propranolol administration for 6 to 12 days. In both hyper-and hypothyroid patients the studies were repeated after euthyroid achievement. Increased PRA (1.43± 0.14ng/ml/hr, m±S.E., on recumbent, 2.27±0.2ng/ml/hr on upright position) and aldosterone concentration (149±20pg/ml, 236±30pg/ml) were observed in hyperthyroidism. These values were both significantly high compared with normal controls (PRA: 0.29± 0.03, 0.74± 0.08, aldosterone: 67± 8, 110± 5). Increased PRA and aldosterone concentration in hyperthyroid patients were both significantly reduced after propranolol administration, but the extent of reduction was much greater in PRA than in aldosterone concentration. In hypothyroidism both PRA (0.23± 0.05, 0.27± 0.06) and aldosterone concentration (23± 3, 36± 8) were significantly low. Those increased and reduced PRA and aldosterone concentration were normalized after achievement of euthyroid states. Serum, potassium levels in these 3 groups were all within normal range and there was no significant difference among these groups. Changes of plasma aldosterone concentration were considered to be secondary to changes of PRA because of parallel changes of these parameters. Clinical significance of altered plasma aldosterone is discussed.
