抄録
The recent discovery of the stimulatory effect of gastrin or pancreozymin on the secretion of calcitonin in the pig has prompted us to study the gastrointestinal effect of calcitonin in rats.
The marked increase in the gastric acid and pepsin accumulation in rats in which the pylorus was ligated for 9hr was significantly inhibited by the prior treatment with 2 MRC U of purified porcine calcitonin.
This inhibitory effect of porcine calcitonin on the gastric acid and pepsin accumulation was dose dependent. Furthermore, the development of acute gastric ulcer in these rats was completely prevented by the s.c. administration of 2 MRC U of porcine calcitonin.
