抄録
Effects of norethisterone (NT) purified norethisterone (pure NT), norethynodrel (NE), medroxyprogesterone acetate (MAP), chlormadinone acetate (CMA) and desoxycorticosterone acetate (DOCA) on serum and liver lipid levels and serum lipoproteins were examined in both intact and estradiol-treated male rats.
NT and NE caused a decrease in serum cholesterol and phospholipid levels, an increase in liver cholesterol level, no significant change in triglyceride levels of both serum and liver, with a significant change in serum lipoprotein patterns; a decrease in α-and β-lipoproteins and a marked increase in pre β-lipoprotein. Pure NT decreased serum cholesterol without causing any change in lipoprotein pattern. MAP, CMA and DOCA caused almost no effect on lipid levels in serum and liver, but CMA and DOCA increased α-lipoprotein and decreased β-and pre β-lipoproteins. An acute treatment with estradiol caused a decrease in α-and β-lipoproteins and an increase in pre β-lipoprotein with a decrease in serum lipid levels and an increase in liver lipids. By contrary, a chronic treatment with estradiol caused an increase in α-lipoprotein and a decrease in β-lipoprotein with a marked hypercholesterolemia. This increase of α-lipoprotein in estradiol-treated rats was prevented by NT and NE, not affected or rather decreased by MAP but further increased with CMA and DOCA.
These data suggest that the effects of synthetic progestational steroids on lipids are classified into two groups, 19-nortestosterone derivatives and 17a-hydroxyprogesterone derivatives including DOCA. The former caused a decrease in serum lipid levels with an increase of pre β-lipoprotein and a decrease of α-lipoprotein. The latter caused almost no change or a slight increase in serum lipid levels with a decrease in pre β-lipoprotein and an increase in α-lipoprotein, though it was not found in MAP.
